Oral verruciform xanthoma (OVX) is an uncommon benign lesion of the oral mucosa, clinically mimicking various verrucous lesions. This study aimed to describe the clinicopathological characteristics of OVX. Twenty-one patients diagnosed with OVX were collected. The patients’ age, sex, medical history, clinical features, and treatment were reviewed. Archived slides were reviewed, and periodic acid-Schiff (PAS) and immunohistochemical (IHC) staining with CD68, CD1a, and S-100 were performed. OVXs affected 13 males and 8 females (M: F=1.6:1) with a mean age of 52 ± 21 years. The most prevalent site was the gingiva (57.1%), followed by the hard palate (28.5%). The lesions presented as an asymptomatic solitary lesion with verrucous or granular surface, with exception of one case with multiple papules on the hard palate. PAS-positive granules were found in xanthoma cells in 14 (66%) specimens. IHC revealed that xanthoma cells were positive for CD68 and negative for CD1a and S-100 in all specimens. Most lesions were successfully excised, and none of the lesions have recurred. Clinicians should include OVX in the differential diagnosis of various verrucous lesions in the oral cavity to provide appropriate management.

Ⅰ. INTRODUCTION
Ⅱ. MATERIAL and METHODS
Ⅲ. RESULTS
Ⅳ. DISCUSSION
REFERENCES

• 고다은(원광대학교 대전치과병원 구강병리과) | Da-Eun Ko (Department of Oral and Maxillofacial Pathology, Daejeon Dental Hospital, College of Dentistry, Wonkwang University)
• 윤정훈(원광대학교 대전치과병원 구강병리과) | Jung-Hoon Yoon (Department of Oral and Maxillofacial Pathology, Daejeon Dental Hospital, College of Dentistry, Wonkwang University) Corresponding author