High-rise buildings are equipped with TMD (Tuned Mass Damper), a vibration control device that ensure the stability and usability of the building. In this study, the seismic response control performance was evaluated by selecting the design variables of the TMD based on the installation location of the twisted irregular building. To this end, we selected analysis models of 60, 80, and 100 floors with a twist angle of 1 degree per floor, and performed time history analysis by applying historical seismic loads and resonant harmonic loads. The total mass ratio of TMDs was set to 1.0%, and the distributed installation locations of TMDs were selected through mode analysis. The analysis results showed that the top-floor displacement responses of all analysis models increased, but the maximum story drift ratio decreased. In order to secure the seismic response control performance by distributed installation of TMDs in twisted irregular buildings, it is judged that the mass ratio distribution of TMDs will act as a key variable.