In this research, the concrete breakout strength in tension of cast-in-place anchors (CIP) is experimentally investigated to be used as fundamental data for the seismic fragility analysis of equipment in nuclear power plants. Experimental variables are chosen, such as the embedment depth of the anchor, single/group anchor configurations, diameter of the head plate, and crack width. Monotonic and cyclic loading are applied to all types of specimens. As measured from the experiments, concrete breakout strength in tension is 1.5 to 2 times higher than the expected strengths from concrete capacity design (CCD) method-based model equations. In alignment with the model’s predictions, concrete breakout strength increases with deeper embedment depth, and the strength of group anchors also increases based on the expansion of the projected concrete failure area. This study also explores the effects of head plate diameter and crack width, which are not considered in the model equation. Experimental results show that the diameter of the head plate is not directly correlated to the concrete breakout strength, whereas the crack width is. The presence of cracks, with widths of 0.3 mm and 0.5 mm, leads to reductions of approximately 7% and 17%, respectively, compared to single anchors in non-cracked concrete.