Background: Chronic low back pain (CLBP) is a common health problem among female caregivers. In Korea, 70.4% of caregivers experience LBP after caregiving. The prevalence of LBP was higher in female caregivers of patients who required physical assistance with transfer than in those caring for patients who did not require physical assistance. Lifting movements, such as patient transfer and positioning, are associated with lumbopelvic stability (LPS) and knee muscle strength. However, no studies have investigated the differences in LPS and knee muscle strength between female caregivers with and without CLBP. Objects: This study was conducted to investigate the differences of the LPS, knee extension strength (KES) and knee flexion strength (KFS) between female caregivers with and without CLBP. Methods: Thirty-one female caregivers participated in this study. Participants were divided into two groups: (1) caregivers without CLBP (n = 13) and (2) caregivers with CLBP (n = 18). LPS, KES, and KFS levels were measured. An independent t-test was used to compare the LPS, KES, and KFS between caregivers with and without CLBP. The statistical significance was set at α of 0.05. Results: The LPS and KES scores were significantly lower in caregivers with CLBP than those without. In contrast, the KFS did not differ significantly between the groups. Conclusion: This study observed associations of both LPS and KES with CLBP among female caregivers.