This study was carried out in a cold storage chamber with a floor space of roughly 3.3 square meters (1 pyeong). The findings revealed that the hybrid cooling system consumed a comparable amount of electricity to that of the conventional vapor compression system. This similarity in power usage can be attributed to the hybrid system’s operational strategy: thermoelectric modules were selectively activated during periods of frost accumulation, effectively minimizing the energy typically used for electric defrosting in vapor compression units. To advance the commercialization of this hybrid system in cold storage applications, several technical improvements must be considered in addition to cost optimization. First, the design should address the bulky nature of the heat exchanger setup. At present, the vapor compression and thermoelectric modules are housed in separate outdoor units; a more efficient approach would involve integrating them into a single, space-saving unit. Second, incorporating a water mist spray mechanism for the outdoor heat exchanger coil could enhance heat dissipation. This method, which leverages latent heat exchange, has demonstrated strong performance in other applications and merits further investigation for use in the proposed system.