The world's largest diesel power plant listed in the Guinness Book of World Records is Jordan's Amman Asian power plant, which produces a total of 573 MW of electric power. It consists of 38 units of 15MW capacity, and KEPCO achieved high profitability through the power plant. If a large capacity of 50MW clsss is applied, it will be newly listed in the Guinness Book of World Records even if only 12 units are constructed. Therefore, large-scale overseas orders for diesel power plants that require large capacity are expected in the future. The purpose of this study is to derive a installation offset by performing the shaft alignment analysis for large capacity 50MW shaft system. As a result, the offset of shaft system for the 50MW diesel power generation equipment was successfully derived through the bearing influence assessment and introduction of arrangement slope for main engine bearings.