Esophageal perforation can be caused by Boerhaave syndrome, foreign body ingestion, trauma, operative injury, or tumors. The condition can be fatal and requires emergency treatment. In this case report, we describe an esophageal perforation following gastric calibration tube insertion during laparoscopic sleeve gastrectomy. The female patient developed an esophageal perforation after gastric calibration tube insertion during laparoscopic sleeve gastrectomy, even though there were no complications during the tube insertion. She had mucosal inflammation of the distal esophagus stemming from gastroesophageal reflux disease. Therefore, the perforation has occurred because the repeated adjustments of the calibration tube may have further damaged the mucosal area that was already weakened by gastroesophageal reflux disease. It is estimated that even slight mucosal inflammation can heighten the risk of esophageal perforation. We hope this report will help elucidate the causes and probability of encountering esophageal perforation due to mucosal inflammation.