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Influence of lidocaine and meloxicam on post-ovariohysterectomy oxidative stress markers (GPx, CAT, MDA) in dogs KCI 등재
- 언어ENG
- URLhttps://db.koreascholar.com/Article/Detail/446610
pp.139-144
Background: This study evaluated the impact of intra-abdominal lidocaine and systemic meloxicam, alone and in combination, on oxidative stress biomarkers in healthy dogs undergoing elective ovariohysterectomy (OHE). Methods: Twenty-eight female dogs presenting to the Aydın Adnan Menderes University Veterinary Teaching Hospital were randomly assigned to one of four groups (n = 7 each): Control (OHE only), Lidocaine (1 mg/kg sprayed intraperitoneally at surgical sites), Meloxicam (0.2 mg/kg SC post-closure), and Lidocaine + Meloxicam (both treatments as above). Blood was sampled pre-operatively and at 2, 12, and 24 hours post-surgery. Serum concentrations of malondialdehyde (MDA), catalase (CAT), and glutathione peroxidase (GSH-Px) were quantified as indices of lipid peroxidation and antioxidant capacity. Results: In the combined-treatment group, MDA, CAT, and GSH-Px levels declined significantly over time, indicating attenuated oxidative stress. In contrast, lidocaine alone produced a significant time-dependent decrease only in CAT activity, while meloxicam alone did not significantly alter any marker. Conclusions: These findings suggest that the synergistic use of intraperitoneal lidocaine with systemic meloxicam more effectively mitigates postoperative oxidative stress than either agent alone, and may represent a beneficial analgesic–antiinflammatory strategy in canine OHE.
INTRODUCTION
MATERIALS AND METHODS
Ethical approval and consent
Animals and experimental design
Anesthetic and surgical protocol
Blood sampling and biochemical assays
Statistical analysis
RESULTS
DISCUSSION
CONCLUSION
REFERENCES
