This study analyzed 366 serious industrial accidents related to machinery and equipment that occurred over the past three years (2021–2023) to investigate the preventive effectiveness of the Industrial Safety and Health Standards. The analysis focused on key variables such as the type of work (regular/irregular), type of accident (entanglement, fall, crushing, etc.), 4M factors (Man, Machine, Media, Management), and accident preventability under compliance with safety regulations. The results indicate that approximately 75.7% of all accidents could have been prevented through compliance. Irregular work showed both a higher risk of accident occurrence and a statistically significant association with preventability. In particular, ten major types of machinery, including forklifts, cranes, and conveyors, accounted for 57.9% of all cases. In addition, 37.2% of accidents occurred involving equipment without specific safety rules. These results indicate that some provisions of the current regulations do not sufficiently reflect the realities of actual industrial sites. They suggest the need for field-oriented revisions of the regulations that incorporate newly emerging machinery types and the evolving realities of the workplace.