This study aimed to compare demographic characteristics, working conditions, and MSD hazardous factor exposure between construction and non-construction workers using the 7th Korean Working Conditions Survey data, and to analyze factors affecting work-related health problems among construction workers to empirically identify their health vulnerabilities. This study utilized raw data from 50,195 respondents of the 7th Korean Working Conditions Survey conducted by the Korea Occupational Safety and Health Agency in 2023. Variables included musculoskeletal disorder risk factors, atypical work arrangements, health problems, and work-relatedness. Descriptive statistics, -tests, and logistic regression analyses were performed. Construction workers were predominantly male (86.7%) with notable aging trends (43.0% aged 51-65). Construction workers showed significantly higher exposure to MSD hazardous factors compared to non-construction workers. Construction workers are exposed to significantly more musculoskeletal hazardous factors and experience work-related health problems more frequently than non-construction workers. Tailored occupational safety and health management measures considering the specificity of the construction industry are needed, and urgent development of health protection measures through work environment improvement for construction workers is required.