As the widespread adoption of autonomous vehicles is anticipated, a greater diversity of occupant postures is expected. However, current vehicle safety systems are not adequately designed to accommodate these varied postures, particularly relaxed seating positions, in which severe injuries have been reported during frontal collisions. Therefore, it is essential to investigate the biomechanical responses and injury tolerances of occupants in relaxed postures. In this study, the head kinematics and injury responses of the Hybrid-III and THOR anthropomorphic test devices, as well as the THUMS human body model, in a relaxed posture are analyzed using frontal impact sled simulations equipped with the sled system model developed in the previous study. The simulation results are evaluated through comparison with post-mortem human surrogate data. The findings of this study are expected to contribute to the fundamental design of new head restraint systems for human heads in autonomous vehicles.