This study conducted nonlinear static analyses to evaluate the effect of structural eccentricity on the seismic performance of piloti-type buildings. Analytical models reflecting the actual structural details of buildings acquired and operated by the Korea Land and Housing Corporation (LH) and the Seoul Housing and Communities Corporation (SH) were developed, and eccentricity ratios were considered as key analytical parameters. The effects of eccentricity on structural response were quantitatively assessed through the evaluation of performance points, plastic hinge distribution, axial load sharing ratio, and interstory drift ratio. The analytical results demonstrated that increasing eccentricity caused the performance point to approach the maximum load and concentrated plastic hinges at the ground story, leading to a noticeable degradation in overall seismic performance. Furthermore, when the eccentricity exceeded approximately 8%, the interstory drift ratio at the ground story tended to surpass the allowable limit specified in the national seismic performance evaluation guidelines. Accordingly, maintaining the eccentricity ratio below approximately 5% is suggested as a rational design strategy to ensure stable seismic performance. The findings provide valuable insights for improving seismic performance evaluation methods and design criteria for piloti-type structures.