논문 상세보기
pp.68-82
This animal experiment aimed to examine the anti-obesity effects of dried Platycodon grandiflorum extract (PG) and Beopje Platycodon grandiflorum extract (PGB) in a high-fat diet-induced obesity model. The study analyzed fat tissue weight, blood lipid levels, and tissue histology. After orally administering PG (250 mg/kg BW) and Beopje PG (250 and 500 mg/kg BW) for 28 days, significant reductions in body weight, which increased due to the high-fat diet (HF), were observed. Additionally, the food efficiency ratio improved, and the weight of regional fat tissues decreased. Blood triglycerides, total cholesterol, and LDL-cholesterol levels were significantly reduced. HDL cholesterol levels in the PG, PGB-L, and PGB-H groups significantly increased compared to the HF group, confirming that Beopje PG extract positively affects blood lipid levels. The elevated levels of blood TNF-α, IL-6, and IL-1β induced by the high-fat diet were significantly reduced in the PG, PGB-L, and PGB-H groups. Histological analysis of the liver confirmed that the administered Platycodon grandiflorum extract reduced lipid deposition and decreased adipocyte size. Therefore, Beopje processing enhanced the functionality of Platycodon grandiflorum extract, indicating its potential as a functional material for obesity management.
서 론
재료 및 방법
1. 시료 제조
2. 실험동물 사육조건
3. 고지방식이로 비만동물모델 유도
4. EchoMRI 분석
5. 동물 조직 및 혈액 채취
6. 혈중 지질농도 및 생화학적 지표 분석
7. H&E 염색
8. 통계 분석
결과 및 고찰
1. 실험동물의 체중, 체중증가율 및 식이효율 변화
2. 지방조직 무게 변화
3. 장기무게 변화 결과
4. 체성분(수분과 지방) 변화
5. 혈중 생화학지표 농도 변화
6. 혈중 지질 농도의 변화
7. 혈중 염증인자 TNF-α, IL-6 및 IL-1β 농도
8. 간 및 지방조직의 병리학적 변화
요약 및 결론
References
