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Sodium Carboxymethylcellulose가 개복 수술한 한국흑염소의 생식기 유착 방지에 미치는 영향 평가 KCI 등재

Reduction of Postsurgical Adhesion Formation of Reproductive Tract with Sodium Carboxymethylcellulose in Korean Black Goats

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  • URLhttps://db.koreascholar.com/Article/Detail/47513
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한국동물생명공학회지 (구 한국수정란이식학회지) (Journal of Animal Reproduciton and Biotechnology)
한국동물생명공학회(구 한국수정란이식학회) (Journal of Animal Reproduction & Biotechnology)
초록

Sodium carboxymethylcellulose(SCMC)와 Hyaluronic acid(HA)가 수정란 이식 및 채란을 위한 복강 수술 후 생식기의 유착 방지 효과 여부를 확인하기 위하여 본 실험을 수행하였다. 실험 동물로 성숙한 암컷 한국 흑염소 20두를 대조군, saline 투여군, SCMC 1%, SCMC 2% 및 HA 0.4% 투여군에 각각 4마리씩 배치하였다. 수정란 채취를 위한 통상적인 방법의 수술을 시행한 후 약물 주입용 카테터를 절

This study was performed to evaluate the efficacy of sodium carboxymethylcellulose (SCMC) for the prevention of postoperative uterus and ovary adhesion formation in the Korean black goats. Twenty adult female Korean black goats randomly were divided into five groups with four animals in each group. After the routine laparotomy, catheter for injection was inserted into the abdomen. Before abdominal closure, saline, 1% SCMC, 2% SCMC or 0.4% HA solution (50ml/10kg of body weight/head) were injected in the abdominal cavity in each group. Three weeks after surgery, second laparotomy was performed and the adhesions were scored on a scale of 0 to 10 according to their vascularity and adhesion size in uterus and ovary. This trial was repeated the four times with the interval of three weeks. In the first and second trial, the group treated with 2% SCMC significantly reduced the adhesion formation than other treatment groups (P<0.05). In the third trial, the adhesion formation was significantly reduced in 2% SCMC and 1% SCMC (P<0.05). In the fourth trial, 2% SCMC reduced the adhesion formation. However, there was no significant difference among other groups. This study showed that the 2% SCMC administered at the end of the surgery reduced the adhesion formation in the Korean black goats.

저자
  • 신현국(충남대학교 수의과대학.동물의과학연구소)
  • 최윤석(충남대학교 수의과대학.동물의과학연구소)
  • 이승재(충남대학교 수의과대학.동물의과학연구소)
  • 이두수(한미약품 연구센터)
  • 조종기(충남대학교 수의과대학.동물의과학연구소)
  • 신상태(충남대학교 수의과대학.동물의과학연구소)