Cloning by nuclear transfer in mammals using somatic cells has enormous potential applications. However, somatic cloning has been inefficient in all species in which NT is successful. High abortion and fetal death rates have been observed. These developmental defects have been attributed to incomplete nuclear reprogramming by the somatic cloning process. In this review, we will discuss studies conducted in our labs to understand the nuclear reprogramming process.

• Tian, X.Cindy
• Xu, Jie
• Xue, Fei
• Kubota, Chikara
• Du, Fuliang
• Yang, Xiangzhong