논문 상세보기

허혈성 뇌졸중 유발 백서에서 수중운동이 하지근 및 대뇌의 HSP 70 발현에 미치는 영향 KCI 등재

Effects of Swimming Exercise on Hind-Limb Muscles and HSP 70 Expression in the Ischemic Stroke Model of Rats

  • 언어KOR
  • URLhttps://db.koreascholar.com/Article/Detail/5976
구독 기관 인증 시 무료 이용이 가능합니다. 4,000원
한국전문물리치료학회지 (Physical Therapy Korea)
한국전문물리치료학회 (Korean Research Society of Physical Therapy)
초록

Ischemic stroke results from a transient or permanent reduction in cerebral blood flow that is restricted to the territory of a major brain artery. Thus, this study was performed to examine (1) the effects of swimming exercise on the improvement of muscle atrophy, and (2) exercise and HSP 70 expression in an ischemic stroke model induced by middle cerebral artery occlusion. The results of this study were as follows: One week after ischemic stroke was induced, changes appeared in the muscle weight of the gastrocnemius muscle due to muscle atrophy in the affected side. Group II showed statistically significant difference from group III eight weeks after ischemic stroke was induced. (p<.05). One week and eight weeks after ischemic stroke was induced there was significant decrease in the relative muscle weight of the gastrocnemius muscle in each group except Group IV, while there was statistically significant increase in group II eight weeks after ischemic stroke was induced, compared to group III (p<.05). For neurologic exercise behavior tests, Group II generally had the highest score, compared to other groups. In immunohistochemical observations, Group II showed a decrease in HSP 70. The above results suggest that swimming exercise improved muscle atrophy, changed the HSP 70 expression of ischemic stroke in rats, and contributed to the improvement of exercise function.

저자
  • 김기도(동신대학교 물리치료학과) | Gi-do Kim
  • 김은정(동신대학교 물리치료학과) | Eun-jung Kim
  • 천진성(동신대학교 물리치료학과) | Jin-sung Chun
  • 김경윤(동신대학교 물리치료학과) | Kyoung-yoon Kim
  • 김계엽(동신대학교 물리치료학과) | Gye-yeop Kim 통신저자
  • 유영대(광주 원광한방병원 물리치료실) | Young-dae Yoo