This paper reports a part of research work on earthquake resistance consideration in regions of moderate seismicity, which is being carried out in the Department of Civil Engineering, Hong Kong University of Science & Technology. The possible seismic hazard in Hong Kong, which is located in a region of moderate seismicity, is described. A case study is presented to compare the wind and earthquake effects on Hong Kong buildings and to assess whether seismic analysis and desing is necessary for building structure. Potential problems of reinforced concrete buildings under earthquake effects in regions of moderate seismicity are discussed.