Cerebral infarction is one of the leading causes of death worldwide and the most common cause of death from a singledisease in South Korea. Each year, 795,000 people in the U.S. experience a new or recurrent stroke. Approximately 15-30% of cerebral infarctions are of embolic origin related to cardiac abnormalities. Because determination of the etiology of cerebral infarction is crucial to acute management and future prevention, clinicians should pay attention to finding the cardiac source of embolism in patients with cerebral infarction. We report on a case of cerebral infarction by a small papillary fibroelastoma on the mitral valve. The patient was treated with open heart surgery and closure of the patent foramen ovale to prevent further embolic events.