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pp.57-64
The aim of this study was to examine the promoting effect of herbal extracts on hair regrowth in C3H/HeJ mice. The herbal extracts were obtained from the Damo-cosmetics Inc. There were four experimental groups including distilled water (D. W., negative control), 20% ethanol (EtOH, vehicle control), 3% minoxidil (MXD, positive control), and herbal extract (Ext). The herbal extract included the mixture of water and alcohol extract from Pleuropterus multflorus, Lonicera japonica Thunberg, Phellinus linteus, and Phaseolus radiatus. Test compounds were applied to the shaved dorsal skin of mice mouse for 3 weeks. The photograph of hair regrowth was taken at day 0, 4, 7, 10, 14, 17, and 21. The herbal extract group showed faster hair regrowth than negative control group or 20% EtOH groups after 10 and 14 days of treatments. The elongation of hair follicles in MXD and the herbal extract groups were observed. The activities of alkaline phosphatase (ALP) and γ-glutamyl transpeptidase were sfanificantly (γ-GT) increased in MXD and herbal extract groups compared with negative control group (p＜0.05). The expression of epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF) were also sfanificantly hfaher in MXD and herbal extract group than negative control group (p＜0.05), althouah there were no sfanificant differences amoularhe groups of 20% EtOH, MXD, and herbal extract. These results suagest that the herbal extract used in this study may have grpromoting effect on hair regrowth by increasing activities of ALP and γ-GT and expression of EGF and VEGF.
