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The Possibility of Liver and Lung Carcinogenesis Induced by Diethylnitrosamine in Newborn B6C3F₁ Mice

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  • URLhttps://db.koreascholar.com/Article/Detail/847
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충북대학교 동물의학연구소 (Research Institute of Veterinary Medicine, Chungbuk National University)
초록

Liver cancer represents a major health problem with steadily increasing incidence rates. Hepatocellular carcinoma (HCC) is the fifth most common cancer and the third most common cause of cancer-related death. This study was conducted in order to investigate the gross findings following treatment with diethylnitrosamine (DEN) in mice. Sixteen male and female mice (B6C3F1), initially 20 days of age, received intraparietal injection (20 mg/kg three times for a period of two weeks, IP) or were given drinking water (DW) containing 50 ppm DEN; all mice were sacrificed at the 80th week of experiments. Hepatocellular adenoma (HCA) and HCC were induced in B6C3F1), mice by administration of DEN. The numbers of HCA and HCC were 7.4±1.72 (IP) and 7.2±0.86 (DW) in male mice. However, no significant difference was observed between the DW and IP groups. The numbers of HCA and HCC were 0.67±0.33 (IP) and 2.0±0.63 (DW) in female mice. This study showed a tendency for high incidences of liver tumor with long-term exposure of newborn animals by drinking water.

저자
  • Dae Joong Kim(College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University) Corresponding author
  • Tae Myoung Kim(College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University)
  • Tae Jin Shim(College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University)
  • Kyoung Mo Yang(College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University)
  • Jin Seok Kang(Department of Biomedical Laboratory Science, Namseoul University)