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Synthesis of Methyl Aryloxy Gallates and Their Inhibitory Activity of NF-κB and Cytotoxicity
- 언어KOR
- URLhttps://db.koreascholar.com/Article/Detail/877
4,000원
Vol. 13 No. 2 (2012.06)
pp.171-179
pp.171-179
충북대학교 동물의학연구소
(Research Institute of Veterinary Medicine, Chungbuk National University)
초록
A series of novel diaryl ether analogs possessing gallate moiety were synthesized and NF-κB inhibitory activity and cytotoxicity were evaluated. NF-κB luciferase activities in prostate LNCaP and colon cancer HCT116 cells showed that 2a, 2c, 2d, 2g, and 2i had potent to moderate inhibitory activities. In addition, 2a exerted more potent cytotoxicity than the reference compound, obovatol, against prostate (LNCaP and PC-3) and colon cancer (HCT116 and SW620) cells.
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