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Potential of Lilium lancifolium in Alleviating Pain and Inflammation in a Rat Model of Monosodium Iodoacetate-Induced Osteoarthritis KCI 등재
- 언어ENG
- URLhttps://db.koreascholar.com/Article/Detail/404431
pp.638-644
Lilium lancifolium (LL) is widely cultivated in East Asia and used to attenuate airway diseases. Our current study aimed to investigate the therapeutic effect of LL on pain level and inflammatory response in a rat model of monosodium iodoacetate (MIA)-induced osteoarthritis (OA). We first examined the effect of LL on inflammatory cytokines and inflammatory mediators in IL-1β-treated HTB-94 cells. The LL extract was found to significantly inhibit the levels of Interleukin-6 (IL-6), Interleukin-8 (IL-8), and prostaglandin-E2 (PGE-2) in Interleukin-1 β (IL-1β)-stimulated HTB-94 cells in a dose-dependent manner. Moreover, chronic oral administration of LL effectively restored the weight-bearing distribution in the rat model of MIA-induced OA. In addition, administration of LL inhibited inflammatory cytokines and inflammatory mediators, such as C-reactive protein (CRP), IL-6, leukotriene B4 (LTB-4), PGE-2, and matrix metalloproteinase-9 (MMP-9). Our findings collectively suggested LL as one of the potential therapeutic agents for OA, owing to its properties of reducing pain and inflammatory responses.
Introduction
Materials and Methods
Preparation of L. lancifolium extract
Cell culture
Animals
MIA-induced osteoarthritis
Hind paw weight-bearing distribution
Blood analysis and measurement of cytokine levels
Histopathological examination
Statistical analysis
Results
LL downregulated the level of pro-inflammatory cytokinesin IL-1β-induced HTB-94 cells
Oral administration of LL ameliorated the hind paw weightbearingdistribution in the rat model of MIA-induced OA
Administration of LL alleviated the level of inflammatorymediators in MIA-induced rats
LL alleviated the invasion of inflammatory cells in thejoints of MIA-induced rats
Discussion
References
