HAE-06 extract is a mixture of four medicinal plants, namely Lonicerae Folium et Caulis (Lonicera japonica), Scutellariae Radix (Scutellaria baicalensis), Adenophorae Radix (Adenophora triphylla var. japonica), and Polygonati Oddorati Rhizoma (Polygonatum odoratum var. pluriflorum). The HAE-06 extract demonstrated a concentration-dependent relaxing effect and enhanced cAMP production in bronchial smooth muscle that had been stimulated to contract with acetylcholine. Using a blocker, it was confirmed that the effect was through the β2-adrenergic receptor/cAMP/PKA pathway. In addition, it is thought that the HAE-06 extract has a bronchial smooth muscle relaxation effect by reducing the inflow of Ca2+ through the K+ and Ca2+ channels present in the sarcoplasmic membrane. If research continues in the future, it is believed that it will be possible to use it as a material for pharmaceuticals and functional foods.

Abstract
서 론
재료 및 방법
    1. 천연물 복합 소재(HAE-06)의 추출 및 제조
    2. HAE-06 추출물의high performance liquid chromatography(HPLC) 분석
    3. 기관지 분리
    4. 기관지의 장력 측정
    5. 기관지 cAMP의 측정
    6. 통계분석
결과 및 고찰
    1. 천연물 복합 소재(HAE-06)의 함량 분석
    2. HEA-06 추출물의 기관지 이완 효과
    3. HEA-06 추출물의 β2-adrenergic receptor/cAMP/PKA경로를 통한 기관지 이완 효과
    4. HEA-06 추출물의 포타슘(K+) 및 칼슘(Ca2+) 통로 차단시 이완 효과
요약 및 결론
References

• 김대성(한풍제약 연구부) | Dae Sung Kim (Dept. of Research, Hanpoong Pharm & Foods Co.)
• 김혜윰(원광대학교 한방심신증후군연구센터) | Hye Yoom Kim (Hanbang Cardio-Renal Syndrome Research Center, Wonkwang University) Corresponding author