한국식품위생안전성학회지 Vol.37 No.2 (p.114-120)

속방형 및 용출조절형 비타민 C 정제의 용출 특성 비교 분석

Comparative Study of Dissolution Properties of Immediate-release and Controlled-release Type Vitamin C Tablets
키워드 :
Vitamin C,Controlled release,Immediate release,HPLC

목차

ABSTRACT
Materials and methods
   시약
   용출조절 제품 제조
   용출시험
   비타민 C 정량시험
   통계 처리
Results and discussion
   물리적 특성 및 비타민 C 함량
   용출시험 결과
   속방형과 용출조절형의 용출률 비교
국문요약
Acknowledgement
Conflict of interest
ORCID
References

초록

In this study, a comparative dissolution experiment was conducted between an immediate-release and a controlled-release vitamin C tablet applied with a technology to control the dissolution of vitamin C to maintain the vitamin C level in the human body. In order to confirm the dissolution rate (%) of vitamin C tablets, HPLC determination was conducted based on the dissolution test methods in the ‘Korean Pharmacopoeia (No. 2020-88),’ ‘Guidelines on Specifications of Dissolution Tests for Oral dosage Forms,’ and ‘Standard and Specifications for Health Functional Foods (No. 2020-63)’ from Ministry of Food and Drug Safety (MFDS). In addition, the dissolution pattern between the immediate-release tablet and the controlled-release tablet was comparatively analyzed. The analysis result confirmed that the immediate-release vitamin C tablet was 100% dissolved after 45 minutes, while the controlled- release vitamin C tablet was 100% dissolved after 480 minutes (8 hours). Furthermore, the dissolution rate (%) at 60 minutes was slower than that of the immediate-release vitamin C tablet. Based on these results, this study confirmed that the dissolution rate (%) test and development of controlled-release tablets containing vitamin C as the main component a re possible.