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악골 근처의 표재성 엡스타인-바 바이러스 관련 림프증식성 질환의 예후: 2건의 증례보고 및 문헌고찰 KCI 등재

Prognosis of Superficial Epstein-Barr Virus-associated Lymphoproliferative Disorders Near the Gnathic Bone: Two Case Reports and Literature Review

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대한구강악안면병리학회지 (The Korean Journal of Oral and Maxillofacial Pathology)
대한구강악안면병리학회 (Korean Academy Of Oral And Maxillofacial Pathology)
초록

EBV-positive mucocutaneous ulcer (EBVMCU) is an indolent, superficial lymphoproliferative disorder that occurs in either iatrogenic or age-associated immunocompromised patients with latent Epstein-Barr virus (EBV) infection. Although EBVMCU is histologically similar with other lymphoproliferative disorders, such as EBV-positive diffuse large B cell lymphoma, the diseases are classified as distinct entities by the World Health Organization with different clinical manifestations, prognosis, and genetic profiles. EBVMCU commonly shows spontaneous regression by conservative management, reduction or cessation of immunosuppressive treatment, but local progression is possible. Complete remission of disease can be achieved with combination of surgical resection, chemotherapy and local radiation therapy. Herein, we report 2 cases of oral superficial lymphoproliferative disorders arising adjacent to the gnathic bone with striking differences in prognosis and bone involvement. One of the cases induced extensive osteomyelitis in the underlying bone. Furthermore, we discussed the differential diagnosis of EBVMCU and reviewed the former literature.

목차
Abstract
Ⅰ. INTRODUCTION
Ⅱ. CASE REPORT
    1. Case 1
    2. Case 2
Ⅲ. DISCUSSION
Ⅳ. CONCLUSION
REFERENCES
저자
  • 홍진호(연세대학교 치과대학 구강악안면외과학교실) | Jin-Ho Hong (Department of Oral & Maxillofacial Surgery, Yonsei University College of Dentistry, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, Republic of Korea)
  • 조현규(연세대학교 치과대학 구강악안면외과학교실) | Hyeon-Gyu Jo (Department of Oral & Maxillofacial Surgery, Yonsei University College of Dentistry, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, Republic of Korea)
  • 한승용(연세대학교 치과대학 구강병리학교실) | Seung-Yong Han (Department of Oral Pathology, Yonsei University College of Dentistry, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, Republic of Korea)
  • 이재은(연세대학교 치과대학 구강병리학교실) | Jae Eun Lee (Department of Oral Pathology, Yonsei University College of Dentistry, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, Republic of Korea)
  • 조은애산드라(연세대학교 치과대학 구강병리학교실) | Eunae Cho (Department of Oral Pathology, Yonsei University College of Dentistry, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, Republic of Korea)
  • 남웅(연세대학교 치과대학 구강악안면외과학교실) | Woong Nam (Department of Oral & Maxillofacial Surgery, Yonsei University College of Dentistry, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, Republic of Korea) Corresponding author