This study examined the relationship between food safety culture and quality innovation performance within the food manufacturing industry, emphasizing the mediating role of organizational effectiveness. A conceptual framework was developed to define food safety culture across five sub-dimensions: executive leadership, employee engagement, communication, continuous improvement, and customer-focused orientation. Quality innovation performance was assessed in terms of quality improvement, customer satisfaction, and cost reduction. Additionally, organizational effectiveness, encompassing job satisfaction, organizational commitment, and innovation behavior, was also examined as a mediating variable between food safety culture and quality innovation performance. Survey data were collected from employees in food-related companies, and Structural Equation Modeling (SEM) was employed to empirically test the proposed relationships. The analysis reveals that food safety culture exerts a significant positive impact on quality innovation performance. Specifically, a strong food safety culture enhances quality innovation performance, both directly and indirectly, with the latter effect mediated through organizational effectiveness. These findings highlight the role of organizational effectiveness as a critical pathway through which food safety culture drives sustainable improvements in food manufacturing performance. This study offers both theoretical and practical contributions to the literature. From a theoretical perspective, this study advances the literature by linking food safety culture to quality innovation performance and organizational effectiveness, thereby deepening our understanding of how safety-oriented values and practices shape organizational performance. Practically, the results suggest that managers can improve quality and long-term competitiveness by fostering a strong food safety culture. Strategies such as reinforcing leadership commitment, encouraging employee participation, strengthening internal communication, promoting continuous improvement initiatives, and embedding customer-focused thinking are essential for institutionalizing a food safety culture into organizational routines. By implementing these strategies, companies can achieve both enhanced food safety while simultaneously strengthening long-term organizational sustainability.