Thailand suffers from one of the highest rates of dengue and dengue haemorrhagic fever in the world. Since there is no vaccine or any specific treatments for dengue, currently, the only effective way to prevent dengue fever and dengue hemorrhagic fever is vector control. The knowledge of basic biology, ecology, behavior and survival factors of Ae. aegypti is crucial to control mosquitoes. The impact of the environmental factors; temperature, rainfall, and humidity, on the ecology, biology, development, vector density, behavior, fitness of mosquito vectors, and the mosquito-borne disease transmission dynamics will be presented and discussed.