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        검색결과 2

        1.
        2025.06 KCI 등재 구독 인증기관 무료, 개인회원 유료
        This case report describes a 40-year-old captive male hippopotamus exhibiting systemic clinical signs, including anorexia and coughing, prior to death. Despite comprehensive medical treatments, the animal died due to age-related immunodepression, which led to severe pneumonia. Necropsy and subsequent histopathological examination revealed severe acute diffuse seropurulent bronchopneumonia, right ventricular hypertrophy, hepatic congestion, and glomerulonephritis. These findings highlight the vulnerability of geriatric large animals to systemic infections and emphasize the need for improved pathological understanding and the development of evidence-based treatment protocols for these less-studied species like the hippopotamus. To enhance disease management and veterinary care for aging zoo animals, future research should prioritize gut microbiome analysis and antimicrobial resistance profiling.
        3,000원
        2.
        2025.06 KCI 등재 구독 인증기관 무료, 개인회원 유료
        Emerging RNA viruses continue to pose serious threats to animal and human health, necessitating the development of broad-spectrum antiviral agents within a One Health framework. In this study, we evaluated the antiviral potential of Desmodesmus multivariabilis extracts against three representative RNA viruses: influenza A virus (IAV), porcine epidemic diarrhea virus (PEDV), and hepatitis A virus (HAV). Extracts derived from four closely related microalgal isolates were tested using pre- and post-treatment protocols in vitro. Among them, strain ME749 demonstrated the most potent and consistent antiviral activity, with low cytotoxicity and high selectivity index (SI), particularly against IAV (SI = 23.8), followed by PEDV (SI = 10.7) and HAV (SI = 6.2). ME752 also showed moderate antiviral efficacy. RT-qPCR confirmed significant reductions in viral RNA levels for all three viruses, with ME749 achieving up to 3-log₁₀ reduction in IAV and 2.4-log₁₀ reduction in HAV. These results suggest that the antiviral effect may be mediated through mechanisms beyond direct virucidal activity, potentially involving host immune modulation. Although the active compounds remain unidentified, carotenoids are hypothesized as key bioactive components. This study highlights Desmodesmus multivariabilis, particularly ME749, as a promising source of novel, natural antiviral agents with applications in both veterinary and zoonotic disease control. Future studies including metabolomic profiling, mechanism-of-action analyses, and in vivo validation are warranted to further explore its potential in combating current and emerging RNA virus threats.
        4,000원