Despite over eighty percent of industrial accidents were caused by unsafe behaviors, most safety programs still focus on changing workers’ internal status such as thinking and attitude rather than directly changing safe related behaviors. The purpose of this paper is to introduce the basic concepts and procedures of Behavior-Based Safety (BBS) which originated in applied behavior science (ABS), BBS attempts to change safety related behaviors by manipulating antecedents and consequences of workers’ behaviors. Also this paper introduces several case studies conducted globally in various industrial fields. These case studies highlight the procedures of BBS, their impacts on safety performance and accidents rate, and other business results. Based on these results, this paper proposes new guidelines for safety management.