The manuscript examines Guanxi’s direct influence on reducing opportunism and conflicts, and its indirect influence on increasing buyers’ satisfaction, relationship performance and long-term orientation. The findings based on data collected from 273 Chinese firms reveal that Chinese buyers’ guanxi with US suppliers could significantly reduce buyers’ perception in suppliers’ opportunistic behaviour and the perceived levels of conflicts in Sino-US relationships, hence increasing their satisfaction, relationship performance and long-term orientation. The results broaden existing understanding of guanxi literature by empirically examining Guanxi’s influence on supplier opportunism and conflicts. The research implications suggest guanxi could be employed as a management mechanism in reducing supplier opportunism and conflicts, hence positively increasing satisfaction, performance and long-term orientation.