Nuclear power plants, which are important national facilities, require special attention against the threat of terrorism using various methods. Among the terrorist threats, as structural damage and human casualties due to explosions continue to occur, interest in the blast load is increasing. However, domestic nuclear power plants do not have sufficient design requirements for protection against the threat of explosives. To prepare for the threat of terrorism using explosives, it is necessary to evaluate the physical protection performance of nuclear power plants against blast load, and to use this to improve protection performance and establish regulatory standards. Most of the explosion-proof designs used abroad use the empirical chart presented by UFC 3-340- 02 (DoD 2008), which does not take into account the effect of near-field explosions. When explosions occur inside nuclear power plants, near-field explosions occur in most cases. In this study, it was assumed that explosives were installed in the corridor inside nuclear power plants. A spherical TNT was placed in the middle of the corridor floor to simulate near-field explosions, and the structure response according to the weight of the TNT was evaluated. The corridor was modeled with a reinforced concrete material and the LS-DYNA program was used for analysis. For the explosion model, the Arbitrary-Lagrangian-Eulerian (ALE) analysis technique applying the advantages of the Lagrangian and Eulerian methods were used. By analyzing the pressure history and the degree of deformation of the structure according to the explosion, the degree of threat caused by the explosion was analyzed. Based on the analysis of this study, physical barriers performance database (DB) using Modeling & Simulation (M&S) will be constructed by performing sensitive analysis such as representative structure shape setting, boundary conditions, material of structures, etc. The constructed DB is expected to be used to establish regulatory standards for the physical barriers of nuclear power plants related to explosives.