The ultimate goal of seawater reverse osmosis brine management is to achieve minimal liquid discharge while recovering valuable resources. The suitability of an integrated system of membrane distillation (MD) with sorption for the recovery of rubidium (Rb⁺) and simultaneous SWRO brine volume reduction has been evaluated for the first time. Polymer encapsulated potassium copper hexacyanoferrate (KCuFC(PAN)) sorbent exhibited a good selectivity for Rb⁺ sorption. The integrated MD-KCuFC (PAN) system with periodic membrane cleaning, enabled 65% water recovery. A stable MD permeate flux was achieved with good quality permeate. KCuFC (PAN) showed a high regeneration and reuse capacity. Ammonium chloride air stripping followed by resorcinol formaldehyde resin filtration enabled to recover Rb⁺ from the desorbed solution.