This study was conducted to re-establish the withdrawal time (WT) for ivermectin (IVM) in pigs as part of the introduction of the positive list system (PLS) program. Forty-two healthy pigs were orally administered IVM at doses of 2.4 mg/kg feed (IVM-1, n = 20) and 4.8 mg/kg feed (IVM-2, n = 20) once daily for 7 days. After treatment, tissue samples were collected from four pigs at 1, 3, 5, 7, and 14 days post-administration. Based on a previously established analytical method, residual IVM concentrations in pig tissues were determined using LC-MS/MS. In the IVM-1 group, IVM levels in muscle, liver, kidney, and fat were below the limit of quantification (LOQ) on days 7, 7, 7, and 14 after the final administration, respectively. In the IVM-2 group, IVM levels in muscle, liver, kidney, and fat were below the LOQ on days 7, 14, 7, and 14 after the final administration, respectively. According to the European Medicines Agency guideline on the determination of withdrawal times, the WTs for IVM-1 and IVM-2 in edible pig tissues were established as 8 and 11 days, respectively. In conclusion, the estimated WT of IVM in swine edible tissues was shorter than the currently recommended WT of 14 days for IVM.

This study describes two cases of urolithiasis-related mortality in Asian small-clawed otters (Aonyx cinerea) raised together for over 10 years. Case 1 had multiple renal and bladder stones without clinical signs and died during surgery for stone removal. Case 2, which harbored more extensive renal calculi, also showed no clinical signs but died suddenly from hydronephrosis and renal failure caused by bilateral obstruction of the renal pelvis. In both cases, the uroliths were composed of calcium oxalate. These results highlight the importance of regular examinations in captive otters.

Tracing the water snowline in low-mass young stellar objects (YSOs) is important because dust grain growth is promoted and the chemical composition varies at the water snowline, which influences planet formation and its properties. In protostellar envelopes, the water snowline can be estimated as a function of luminosity using a relation derived from radiative transfer models, and these predictions are consistent with observations. However, accurately estimating the water snowline in protoplanetary disks requires new relations that account for the disk structure. We present the relations between luminosity and water snowline using the dust continuum radiative transfer models with various density structures. We adopt two-dimensional density structures for an envelope-only model (Model E), an envelope+disk+cavity model (Model E+D), and a protoplanetary disk model (Model PPD). The relations between the water snowline, where Tdust = 100 K, and the total luminosity, ranging 0.1–1,000 L⊙, are well fitted by a power-law relation, Rsnow = a × (L/L⊙)p au. The factor a decreases with increasing disk density, while the power index p has values around 0.5 in all models. As the disk becomes denser, the water snowline forms at smaller radii even at the same luminosity, since dense dust hinders photon propagation. We also explore the effect of viscous heating on the water snowline. In Model PPD with viscous heating, the water snowline shifts outward by a few au up to 15 au, increasing the factor a and decreasing the power index p. In Model E+D with lower disk mass, the effect of viscous heating is negligible, indicating that the disk mass controls the effect. The discrepancy between our models and direct observations provides insights into the recent outburst event and the presence of a disk structure in low-mass YSOs.

In this study, we analyzed the structural and mechanical properties of aluminum foams fabricated using aluminum powders of varying sizes and mixtures. The effects of sintering and pore structure at each size on the integrity and mechanical properties of the foams were investigated. Structural characteristics were examined using scanning electron microscopy and micro–computed tomography, while mechanical properties were evaluated through compression testing. The experimental results demonstrated that smaller powder sizes improved foam integrity, reduced porosity and pore size, and resulted in thinner cell walls. In combination, these effects increased compressive strength as the powder size decreased. The findings of this study contribute to the understanding and improvement of the mechanical properties of aluminum foams and highlight their potential for use in a wide range of applications.

본 논문은 라이소자임이 칸디다 알비칸스에 항균효능이 있음을 발견하였고 라이소자임의 분해 절편도 또한 항균효능이 있는지 단백질 분해 효소인 트립신을 처리하여 확인해 보았다. 130개의 아미노산 으로 구성된 14 kDa 단백질인 라이소자임을 약 24 kDa의 분자량을 가지는 단백질 분해 효소인 트립신으 로 분해 하였다. 분해된 생성물은 고성능 액체 크로마토그래피인 분석용 및 제조용 HPLC를 사용하여 분 석 및 분리하였다. 이를 통해 효율적인 라이소자임 소화를 위한 최적 조건을 확인하고, 분해된 펩타이드 절 편들을 분리하였다. 효능평가 결과, 일부 펩타이드 절편들이 칸디다 알비칸스에 강한 항균 활성을 보임을 확인하였으며 몇몇은 활성이 줄어드는 결과를 보였다.

Supercapacitors, renowned for their high power density and rapid charge-discharge rates, are limited by their low energy density. This limitation has prompted the need for advanced electrode materials. The present study investigated reduced graphene oxide (rGO) in two distinct structures, as a film and as an aerogel, for use as supercapacitor electrodes. The rGO film, prepared by vacuum filtration and thermal reduction, exhibited a compact, lamellar structure, while the aerogel, synthesized through hydrothermal treatment, was a highly porous three-dimensional network. Electrochemical analyses demonstrated the aerogel’s superior performance, as shown by a specific capacitance of 121.2 F/g at 5 mV/s, with 94% capacitance retention after 10,000 cycles. These findings emphasize the importance of structural design in optimizing ion accessibility and charge transfer. They also demonstrate the potential of rGO aerogels for increasing the energy storage efficiency of advanced supercapacitor systems.

Fluorescent bacteria were isolated from sporocarps that browned into various mushrooms during survey at places of the production in Korea. We examined the pathogenicity, biodiversity, and genetic characteristics of the 19 strains identified as Pseudomonas tolaasii by sequence analysis of 16S rRNA and White Line Assay. The results emphasize the importance of rpoB gene system, fatty acid profiles, specific and sensitive PCR assays, and lipopeptide detection for the identification of P. tolaasii. As a result of these various analyses, 17 strains (CHM03~CHM19) were identified as P. tolaasii. The phylogenetic analysis based on the 16S rRNA gene showed that all strains were clustered closest to P. tolaasii lineage, two strains (CHM01, CHM02) were not identified as P. tolaasii and have completely different genetic characteristics as a result of fatty acids profile, specific and sensitive PCR, lipopetide detection, rpoB sequence and REP-PCR analysis. Pathogenicity tests showed 17 strains produce severe brown discolouration symptoms to button mushrooms and watersoaking of sporophore tissue within three days after inoculation. But two strains did not produce discolouration symptoms. Therefore, these two strains will be further investigated for correct species identification by different biological and molecular characteristics.