This study examined the influence of ICT on vocational and technical skills acquisition among polytechnic students in Osun State. The sample of the study was 350; consisting of undergraduate students from 2 Polytechnics in Osun State. Self-developed questionnaires were made and validated through pilot testing and administered to the sample for the collection of data. The researcher personally visited respondents, thus 100% of data were collected. The collected data were tabulated and analyzed by using percentage, frequency count and t-test analysis. The major findings of the study were that there is a significant difference in the impact of ICT on vocational and technical skills acquired by students of Polytechnics in Osun State, ICT has a greater impact on vocational and technical skills acquired by male students than that of females. It was also concluded that there is a significant difference in the impact of ICT on vocational and technical skills acquired by students of Polytechnics in Osun State based on specialization. Based on the findings of the study, major recommendations were enumerated as the government should develop ICT software that will be applicable to their indigenous cultures so as to make ICT more relevant to the local needs of the people, educators should be sponsored to attend workshops, seminars, and conferences, both locally and internationally, and educational programmes should be restructured to make them utility oriented, among others.