The innovation and entrepreneurship education system in colleges and universities is a guiding channel to strengthen the innovation ability of talents and to expand their employment scope. It has the characteristics of diversity, innovation and adaptability. Based on this, taking local colleges and universities in China as an example, this article summarizes the current situation of the construction of innovation and entrepreneurship education system, and puts forward relevant suggestions for the practices of system promotion, so as to bring the advantages of the system into full play and realize the comprehensive utilization of talents in colleges and universities.