Background: Limb amputation causes complex physical, psychological, and social problems, yet evidence on International Classification of Functioning, Disability, and Health (ICF)-based multidisciplinary rehabilitation remains limited. Objectives: To report functional and emotional outcomes of an ICF Rehab- Cycle® program in a woman with bilateral transfemoral and transradial amputations. Design: Single-case report (quasi-experimental). Methods: A physiatrist, nurse, physical therapist, occupational therapist, and social worker used the ICF Assessment Sheet, ICF Categorical Profile, ICF Intervention Table, and ICF Evaluation Display over four weeks to set and review goals. Results: Nine of eleven ICF Rehab-Cycle® program targets were achieved. Marked gains were observed in gait and activities of daily living, accompanied by improved emotional well-being through structured psychosocial support. Conclusion: An ICF-guided multidisciplinary approach significantly enhanced physical function, emotional health, and independence after complex limb amputation, underscoring the value of the framework for patient-centered collaborative rehabilitation.