Clues of importance contained in interactive processes between students with cultural diversity and networked systems can offer meaningful insights into effective instructional design. This paper revisits significant and seminal research contributions in the fields of technologically- mediated communication and culture to bring insights into designing effective technologically-mediated learning environments for culturally diverse students. In support this, a wide range of existing researches were reviewed. Mainstream of research focusing paralinguistic cuing and technologically- mediated communication were analyzed and then terms of culture and instructional design were elaborated in an attempt to prove the assumption of the study. Based on the literature presented thus far, there is good reason to conclude that technology-mediated communication involves a complex multimodal process requiring not only speech, but also gaze, gesture, and facial expressions. By furthering our understanding of the impact of cultural diversity in technologically- mediated learning environments, we surely ensure that more effective instructional designs emerge.