This paper studies the factors affecting university and industry collaboration in education in the hospitality industry in Ho Chi Minh City (Vietnam) from a company perspective. The authors use qualitative method and quantitative research to study the matters, specifically using scales and data collected for Cronbach alpha reliability testing, analysizing the discovery factor of EFA, CFA and verifying the regression models through AMOS software with SEM linear modeling. The study proposes four factors: (1) organization factors, (2) contextual factors, (3) process factors, and (4) cooperation perspective impacting on the benefits factors and university and industry collaboration in education. In addition, it is also found that benefits factors has a direct and positive impact on the collaboration in education. The results suggest that the process factor had the strongest positive, followed by the contextual factor. The findings revealed that the benefit factors were significantly related to collaboration in education, which affects university and industry hospitality alliances. This finding confirm that the cooperation perspective (QD) and contextual factors (HC) are critical in collaboration between university and industry. A new point of interest is also identified that the benefits of training links are quite dependent on the linking perspective from tourism businesses.