This study performed a numerical analysis of a 3D unsteady viscous flow in order to investigate ship motion responses running through regular waves of the platform supply vessel. The feasibility of numerical analysis was tested under the three regular wave conditions of the KRISO container ship (KCS) suggested at the 2010 Gothenburg CFD Workshop. The resulting resistance coefficient, heave motion, and pitch angle were compared with the model test of the harmonic analysis. Also, the ship motion response characteristics of the platform supply vessel were performed using the proven method of the KRISO container ship (KCS). The ship motions including the resistance coefficient, heave motion, and pitch angle according to the time series were investigated via harmonic analysis under regular waves condition of λ/LPP=1.87 and HS=0.078m