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        검색결과 55

        1.
        2024.02 KCI 등재 구독 인증기관·개인회원 무료
        Plants synthesize antioxidant compounds as a defense mechanism against reactive oxygen species. Recently, plant-derived antioxidant compounds have attracted attention due to the increasing consumer awareness in the heath industry. However, traditional methods for measuring the antioxidant activity of these compounds are time-consuming and costly. Therefore, our study constructed a quantitative structure-activity relationship (QSAR) model that can predict antioxidant activity using graph convolutional networks (GCN) from plant structural data. The accuracy (Acc) of the model reached 0.6 and the loss reached 0.03. Although with lower accuracy than previously reported QSAR models, our model showed the possibility of predicting DPPH antioxidant activity in a wide range of plant compounds (phenolics, polyphenols, vitamins, etc.) based on their graph structure.
        2.
        2023.09 KCI 등재 구독 인증기관 무료, 개인회원 유료
        Cordycepin (3'-deoxyadenosine) is a nucleoside analog known for its diverse range of biological activities. This study investigated the effect of different types of sawdust on the production of the bioactive compound cordycepin. The results of the study showed that different types of wood sawdust affected the biosynthesis of cordycepin and a significant increase was observed when the conventional SDB medium was replaced with 1% NaOH treated pine sawdust. To optimize cordycepin production from Paecilomyces tenuipes in a medium containing 1% NaOH-pretreated pine sawdust, we employed Response Surface Methodology (RSM) in its Box-Behnken design (BBD) canonical form. The optimal conditions were determined as follows: a particle size of 109.5111-mesh (140 m) for 1% NaOH-pretreated pine sawdust, an input weight of 21.1679 g/L, and an incubation time of 73.8423 hours. According to our model, this combination is expected to yield a maximum cordycepin content of 896.1428 g/mL. Experimental validation of this prediction was performed using the suggested optimal conditions, resulting in an average cordycepin content of 922.6771 g/mL across three replicates, thus confirming the model's accuracy.
        4,000원
        3.
        2023.06 KCI 등재 구독 인증기관 무료, 개인회원 유료
        Roridin E, a constituent of Podostroma cornu-damae, has excellent medicinal properties and exhibits powerful anticancer effects. However, being a poisonous mushroom, P. cornu-damae is difficult to find in its natural environment. Therefore, only a limited amount of roridin E is isolated from P. cornu-damae. We isolated roridin E from mycelial culture medium of P. cornu-damae and examined its effects on five breast cancer cell lines. The purity of the isolated roridin E was 96%. It exhibited anticancer effects on all five breast cancer cell lines, with an IC50 of at least 0.0006 mg/L. To the best of our knowledge, this is the first report on the investigation of effects of roridin E isolated from the mycelium of P. cornu-damae mushrooms on five breast cancer cell lines. However, safety issues should be investigated and addressed in future studies before roridin E is used in clinical settings.
        4,000원
        4.
        2023.03 KCI 등재 구독 인증기관 무료, 개인회원 유료
        This study aimed to verify the whitening effect of Cordyceps militaris, which is distributed in several countries worldwide, including Korea, Japan, and China, and has various medical effects. To screen the efficacy of C. militaris, the inhibitory activity of tyrosinase, which was 66% at a concentration of 1 mg/mL, was measured. Thereafter, the survival rate of melanoma cells was measured, and cell experiments were conducted at a concentration of 90% or more in which C. militaris was not toxic to cells. After measuring the inhibitory effect of TRP-1, TRP-2, tyrosinase protein, and mRNA expression, which are factors influencing melanin synthesis, C. militaris was found to decrease in all factors, with an expression level that was significantly lower compared to quercetin. This confirmed that C. militaris stimulated with LED has excellent whitening activity and can be used as a functional whitening cosmetics material.
        4,000원
        5.
        2022.09 KCI 등재 구독 인증기관 무료, 개인회원 유료
        Cordyceps militaris mycelium extracts containing high amounts of cordycepin were evaluated in vitro for their antiinflammatory and tumor cell growth-inhibitory activities. All extracts dose dependently inhibited the increased production of inflammatory mediators including reactive oxygen species (ROS), nitric oxide (NO), and β-hexosaminidase in lipopolysaccharide (LPS)-stimulated inflammatory cells. All extracts were evaluated for anti-proliferative activity against normal RBL-2H3 cells and diverse types of cancer cell lines, including HCT, MC5-7, U-87MG, AGS, and A549 cells. The extract showed the strongest growth inhibition (IC50 = 28.13 μg/mL) relative to vehicle-treated control cells against fibrosarcoma (MC5-7). We have demonstrated anti-inflammatory activity of C. militaris via inhibition of NO, ROS production, and β-hexosaminidase release in activated cells. C. militaris mycelium extract was also evaluated mechanistically and found to exert six types of anti-cancer activity, confirming its pharmacological potential. Our study suggests C. militaris use as a potential source of anti-inflammatory and anticancer agents. C. militaris may also be considered a functional food.
        4,000원
        6.
        2022.04 KCI 등재 구독 인증기관 무료, 개인회원 유료
        Plant-derived compounds have been reported to possess anti-inflammatory abilities contained inhibited β-hexosaminidase, ROS and NO release. Essential oils are natural volatile complex compounds that are characterized by a strong scent and produced by aromatic plants as various plant-derived compounds. The essential oil extracted from Zanthoxylum coreanum Nakai (Z. coreanum) has various functional properties; however, little information is available regarding its anti-allergic inflammatory. A total of 17 compounds were detected in Z. coreanum oil, and the main component was estragole (50.86%). The tested Z. coreanum oil and estragole statistically inhibited the release of β-hexosaminidase induced by antigen stimulation in RBL-2H3 cells. This Z. coreanum oil and estragole may stimulate the secretion of active oxygen (ROS) or nitric oxide (NO) which are considered to involved in anti-inflammatory events. Moreover, it is suggested that Z. coreanum oil and estragole may negatively control the production of SNARE proteins (VAMP7) at the tran-scriptional and translational levels in common. These results demonstrate that Z. coreanum oil and its major component, estragole, possess potent anti-inflammatory abilities that are coupled with antioxidant properties.
        4,000원
        7.
        2022.03 KCI 등재 구독 인증기관 무료, 개인회원 유료
        Cordyceps militaris, a well-known traditional Chinese medicine, has multiple health-promoting effects. It is used as a herbal remedy and health food in Asian countries. Cultured mycelia are often used as a substitute for natural C. militaris. In the present study, the mycelia and fruiting bodies of artificially cultured C. militaris were analyzed using a metabolomics approach. The protein and crude fat contents of the mycelia were substantially higher than those of the fruiting bodies. The top three abundant amino acids in the mycelia were proline (3.9 g/100 g), aspartic acid (2.9 g/100 g), and glutamic acid (2.7 g/100 g). The carbohydrate content was similar in the fruiting bodies and mycelia. Analysis revealed that both the fruiting bodies and mycelia are rich in phenolic compounds and exhibit antioxidant activity. Further, six metabolites were significantly different between the mycelia and fruiting bodies. The levels of Ca, glucose, Mg, and Se were higher in the mycelia than in the fruiting bodies. In contrast, mannitol and Zn were more abundant in the fruiting bodies. The current study provides a comprehensive metabolic profile of the mycelia and fruiting bodies of artificially cultured C. militaris. Such an exercise is potentially important for understanding the metabolism of C. militaris and facilitating the use of cultured mycelia as a supplement to C. militaris fruiting bodies in traditional Chinese medicine.
        4,000원
        8.
        2022.02 KCI 등재 구독 인증기관 무료, 개인회원 유료
        Gabion was unfavorable to the reconstruction of the landscape caused by limit plant growth because of commonly filled with stone. Therefore, gabion was need substrate as possible to plant growth for harmonize with the surroundings and prevent of erosion. The objective of this study was to evaluate the effect of substrates based growing media containing wood meal on physical property (moisture content), chemical properties (organic matter and C/N ratio), plant cover and plant species in gabion. The substrates were composed of soil and soil mixed with growing media (9:1 (v/v) and 4:1 (v/v)). The growing media was prepared by mixing the basic materials, such as peat, perlite, with the specific materials, such as steam treated wood meal (Quercus mongolica) and NH4NO3. Field experiments were carried out on a damaged forest slope, South Korea, from January to November. The results, the moisture content of soil mixed with growing media (4:1, v/v) was maintained high value than others during the thermophilic period and consistently high organic matter which at an advantage for long term plant growth for 11 months. We were confirmed soil mixed with growing media (4:1, v/v) was an advantage to keep C/N ratio for plant growth period. The growing media based substrates has high plant cover percentage and advantage to plant growth for long term. And to conclude, in general the project is a success considering that few repairs or follow up will be necessary. This technique offers a solution to create a better harmony with the surrounding environment.
        4,200원
        9.
        2021.09 KCI 등재 구독 인증기관 무료, 개인회원 유료
        In this study, we investigated the effect of solid culture medium on the production of cordycepin in Cordyceps militaris. The regression equation was expressed as follows: Y1= 755.3-58.6625X1+4.79432E-14X2-46.6625X3-5.66269E-14X1X2- 0.025X1X3+1.62475E-14X2X3-160.6625X1 2+0.0125X2 2-206.9625X3 2, where, Y represents the value of cordycepin content (μg/g), X1 corresponds to the weight of M. alternatus in solid culture medium (g/bottle), X2 to the water content of the solid culture medium (%), and X3 to the culture period (day). The solid culture medium was optimized using the response surface methodology, and the optimal medium composition was as follows: the weight of M. alternatus in solid culture medium and water content were 16.2% and 100.7% (20.14 mL water/20 g solid culture medium), respectively, with a culture period of 39 days. Under these conditions, the cordycepin content of the fruiting bodies reached 150.0 μg/g (actual value). The supplementation of M. alternatus in solid culture for improved cordycepin content of C. militaris seems to be a promising alternative to wild and solid cultivation.
        4,000원
        10.
        2021.06 KCI 등재 구독 인증기관 무료, 개인회원 유료
        Roridin E, produced by Podostroma cornu-damae, is a mycotoxin with anticancer activity. To increase the content of roridin E, submerged culture conditions were optimized using response surface methodology. Three factors, namely, medium initial pH, incubation time and agitation speed were optimized using a Box–Behnken design. The optimum submerged culture conditions to increase the content of roridin E included a medium with an initial pH of 4.0, an incubation time of 12.90 days, and an agitation speed of 63.03 rpm. The roridin E content in the submerged culture, under the aforementioned conditions, was 40.26 mg/L. The findings of this study can help lower the current price of roridin E and promote its related research.
        4,000원
        11.
        2021.06 KCI 등재 구독 인증기관 무료, 개인회원 유료
        Yield and fruit size are under the control of many interacting factors and crop failures can be caused by climatic extremes and poor flowering. Nevertheless, this study has shown that mulching, through the creation of improved soil properties and reduced environmental stress, has the potential to substantially increase A. arguta fruit size and yield. The mulched site performed better than the site without mulch in reducing soil temperature, increasing soil moisture and controlling available phosphorus. Moreover, mulching improved both yield and fruit size. In light of this, we hope that the results of our research will provide useful information for the cultivation of A. arguta in South Korea. However, it also seems necessary to conduct research on the use of different types of mulch and on the economic profitability of mulch in the future.
        4,300원
        12.
        2021.03 KCI 등재 구독 인증기관 무료, 개인회원 유료
        The choice of the culture medium is an important factor for the mass production of mycelia in submerged cultures. The influence of liquid medium on the mycelial dry weight of Paecilomyces tenuipes was investigated in this study. The regression equation is expressed as Y=-1292.94187+17.78612X1+18.92425X2+2.11464X3-0.019375X1X2-0.006276X1X3+0.008177X2X3- 0.070169X1 2-0.292175X2 2-0.008818X3 2, where Y represents the value of the mycelial dry weight (g/L), X1 is the particle size of wood sawdust in liquid medium (mesh), X2 is the concentration of the wood sawdust in liquid medium, and X3 is incubation time (h). The medium was optimized using a response surface methodology, and the optimal medium contained 30 g of wood sawdust (140 mesh), 20 g of glucose, and 10 g/L of peptone. Under these conditions, the mycelial dry weight reached 38.1 g/L (actual value). The culture medium containing wood sawdust is simple and easy to use, highly efficient, and eco-friendly, and its effectiveness in large preparations of P. tenuipes mycelia with low material costs has been demonstrated.
        4,000원
        13.
        2020.08 KCI 등재 구독 인증기관 무료, 개인회원 유료
        Soil properties are important environmental conditions affecting fruit quality and yield in new cultivars of Actinidia arguta. The yield of three A. arguta cultivars (cv. Autumn Sense, cv. Chungsan, and cv. Greenball) from Wonju city, South Korea was investigated from 2017 to 2019 and the relationships to soil properties are discussed. The yield of cv. Autumn Sense, cv. Chungsan, and cv. Greenball fruits ranged from 6.8 to 24.5, 14.0 to 29.0, and 10.5 to 38.5 kg/vine. cv. Autumn Sense had the highest soil organic matter content and soil C/N ratio over the three-year period. The yield of A. arguta fruits was positively correlated with soil C/N ratio and could be described by a power model (y = axb), suggesting that soil C/N ratio plays an important role in limiting the bioavailability and bioaccumulation of organic matter in A. arguta fruits. In addition, C/N ratio in the soil was influenced by the soil available phosphate. However, the threshold of the C/N ratio for A. arguta fruit differed according to cultivar, and especially the lowest threshold was observed in cv. Chungsan. Therefore, the application of an appropriate C/N ratio depending on the cultivar is required for improved fruit yield. Our results present the soil properties required to increase the yield of the new A. arguta cultivars in South Korea.
        4,000원
        14.
        2020.06 KCI 등재 구독 인증기관 무료, 개인회원 유료
        The road slopes have various problems such as the risk of landslides and soil erosion, and research on stabilizing road slopes using plant greening has attracted the most attention. The overall objective of this research was to evaluate the effects of woody biomass based growing media on plant germination in a slope area. Moreover, we tried to find out what physicochemical properties of growing media affect plant germination on a slope. For experiment, we tested soil, soil mixed with growing media (1:1, w/w), and growing media by itself. Physical and chemical properties were evaluated after a month from the date of treatment application to the experimental slope site. Plant germination of Lespedeza cyrtobotrya was measured for plant growth evaluation. Physicochemical properties were altered by mixing the soil with growing media. Particularly, moisture content, organic matter and C/N ratio were significantly changed in soils mixed with growing media compared to soil alone. We confirmed that plant germination was high when growing media was mixed with the soil. There was a significant linear relationship between particle density and pH of all media tested and plant germination. In addition, in the same trend, the principal component analysis confirmed that the particle density and pH was positive component for plant germination rate, and the C/N ratio was found to be the negative component for plant germination. In conclusion, the particle density, pH and C/N ratio of the soil mixed with growing media was considered effective for plant germination in the experimental slope site, and this wood-based growing media provides a means to improve the harmony between the slope and the surrounding environment.
        4,000원
        15.
        2020.03 KCI 등재 구독 인증기관 무료, 개인회원 유료
        Light is an important factor for cordycepin production in Cordyceps militaris. We investigated the effects of different light-emitting diode (LED) conditions including various LED wavelengths and their combinations on cordycepin production in Cordyceps militaris cultivated in submerged culture. The results of our study showed that the combinations of LED wavelengths were more beneficial than single LED sources for cordycepin production. Among the three tested wavelength combinations, the greatest effects for cordycepin production were observed for the red:blue light combination at the wavelength ratio of 5:5 or 3:7. The optimal culture conditions were 19.2278 h/day of illumination time; 9.19497 g/50 mL of glucose content in the media; and 53.112 h of cultivation time. Our model predicted a maximum yield of 2860.01 μg/mL cordycepin. Finally, to verify the calculated maximum, we performed experiments in the culture media representing the obtained optimum combination and the cordycepin yield of 2412.5 μg/mL.
        4,000원
        16.
        2019.10 KCI 등재 구독 인증기관 무료, 개인회원 유료
        Environmental conditions are important in increasing the fruit sugar content and productivity of the new cultivar Autumn Sense of Actinidia arguta. We analyzed various soil properties at experimental sites in South Korea. A Pearson’s correlation analysis was performed between the soil properties and sugar content or productivity of Autumn Sense. Further, a decision tree was used to determine the optimal soil conditions. The difference in the fruit size, sugar content, and productivity of Autumn Sense across sites was significant, confirming the effects of soil properties. The decision tree analysis showed that a soil C/N ratio of over 11.49 predicted a sugar content of more than 7°Bx at harvest time, and soil electrical capacity below 131.83 μS/cm predicted productivity more than 50 kg/vine at harvest time. Our results present the soil conditions required to increase the sugar content or productivity of Autumn Sense, a new A. arguta cultivar in South Korea.
        4,500원
        17.
        2018.10 KCI 등재 구독 인증기관 무료, 개인회원 유료
        The physical and chemical properties of corrugated cardboard-based media were evaluated to assess their suitability as substrates for plants. Samples were collected periodically from the same study area over 5 months to determine any seasonal variabilities. In addition to the corrugated cardboard-based media, the rural soil of the study area was used as the control. The corrugated cardboard-based media showed adequate levels of moisture content and bulk density and correspondingly high porosity values when compared with the rural soil. All corrugated cardboard-based media showed adequate levels of electrical conductivity, organic matter, and correspondingly high cation exchange capacity values when compared with the rural soil in all seasons. The C/N ratio of the corrugated cardboard-based media was similar to the optimal values of 15-20. However, the pH values of the corrugated cardboard-based media were lower than the optimum value(pH 4) for plant growth and rural soil. The moisture content value which cycle bobs up and down according to sampling date, and this means that the moisture content is affected by seasonal changes in the components entering the study area. The corrugated cardboard-based media appear to be acceptable for growing plants(Lotus corniculatus var. japonicus). Finally, the use of this media permits better vegetation establishment than the use of rural soil. Our results prove that corrugated cardboard-based media can exhibit higher plant cover over a long period(September-November) as opposed to rural soil. Our study demonstrates the effectiveness of corrugated cardboard-based media for plant growth, and we recommend that future studies should focus on potential materials relevant to revegetation and management.
        4,000원
        20.
        2017.06 KCI 등재 구독 인증기관 무료, 개인회원 유료
        본 연구에서는 약용식물 추출물을 함유한 숙취해소 음료가 항산화 및 알코올 분해에 미치는 영향을 조사하기 위하여, 약용식물 추출물의 총 페놀성화합물 함량, 총 플라보노이드 함량 및 DPPH radical 소거활성 및 ALDH(aldehyde dehydrogenase) 활성을 측정하였고, 약용식물 추출물을 함유한 숙취해소 음료의 복용이 음주 후 호흡 중 알코올 농도에 미치는 영향을 조사하였다. 항산화활성은 빼빼목 추출물 에서 높은 수치(total phenolic compound 97.5.6mg/g, total flavonoid 306.5mg/g, DPPH radical 소거능 80.1%)를 나타냈으며 Acetaldehyde(ALDH)에 대한 활성은 헛개 및 울금 추출물에서 306% 및 292%로 가장 높은 활성을 나타내어, 헛개 및 울금 추출물이 ALDH 제거에 효과적인 것으로 나타났다. 헛개 및 울금 추출물이 함유된 숙취해소 음료를 이용하여, 임상실험을 실시한 결과, 시간경과에 따라 대조군에 비해 숙취해소음료 섭취군에서 알코올 농도가 감소되는 경향을 나타냈으며 흡연자에 비해 비 흡연자가, 남성에 비해 여성에게 숙취해소 음료의 섭취가 더 효과적인 것으로 확인되었다.
        4,000원
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