The genus Conicera Meigen is a group of necrophagous phorid flies mostly associated with carrion, including C. tibialis, commonly known as the “coffin fly” that breeds in buried corpses. In this study, specimens of the Conicera species collected from South Korea are examined morphologically on the basis of characteristics on male antennae, sensory organ on midfemora, and left and right surstyli on hypopygium. As a result, five species, viz. C. dauci, C. gracilis, C. orientalis, C. pacifica, C. quadrata are newly recorded from South Korea. Photographs of diagnostic characters, a distribution map and a key to males of South Korean species are provided.

야생 잎새버섯 추출물을 이용하여 심혈관계 질환과 관련된 기능성 식품 개발을 위한 기초자료를 얻기 위해 준비한 물 추출물과 유기용매 분획물의 혈전용해활성과 트롬빈저해활성, acetylcholinesterase 저해활성, 항산화활성을 확인하였다. 10 mg/mL의 농도에서 물 추출물과 물 분획물은 각각 0.93 plasmin unit와 0.73 plasmin unit의 높은 혈전용해활성을 나타냈으며, 부탄올 분획물은 79.60%의 트롬빈저해활성을 나타냈다. 클로로포름 분획물은 85.88%의 높은 acetylcholinesterase 저해활성을 나타냈고, 물 추출물의 항산화 활성은 39.81%로 비교적 낮게 나타 냈다. 부분 정제된 효소를 포함하고 있는 물 분획물은 섬유소원의 Bβ chain를 모두 분해시켰지만, Aα chain은 느리게 분해시키고 γ chain 과는 반응하지 않았다. 실험 결과로부터 야생 잎새버섯 추출물은 높은 혈전용해활성과, 트롬빈저해활성, acetylcholinesterase 저해활성을 나타내 심혈관계 질환 예방을 위한 제약과 기능성식품 개발에 이용 가능할 것으로 기대된다.

본 연구는 학생들의 능동적이고 협력적인 학습활동과 이에 따른 학습 성과를 높이기 위한 문제기반학습(PBL)을 ‘실습선 수업’ 에 맞게 재설계하고 운영한 과정을 제시하였다. 그리고 그 효과로 학생들의 수업참여, 학업적 자기조절 및 학업적 자기효능감의 변화와 수업전반의 만족도를 확인하였다. 그 결과 첫째, 수업참여에 대한 수업 전·후의 차이에서 학습활동, 수업확장, 수업참여 전체의 평균 점수가 높게 나타났다. 둘째, 학업적 자기조절에 대한 수업 전·후의 차이에서 ‘평가’를 제외한 모든 하위요인에서 사후의 평균 점수가 높게 나타났다. 셋째, 학업적 자기효능감에서는 ‘과제 선호도’에서만 유의미한 차이를 보였다. 마지막으로 학생들의 수업전반에 대한 만족도 역시 높은 것으로 나타났다. 교수자 역시 문제기반학습(PBL)을 활용한 실습선 수업을 설계 및 운영하면서 학생 개인의 특성을 파악할 수 있었고, 학생과의 상호작용이 높아짐을 확인할 수 있었다. 이러한 연구결과에 근거하여 문제기반학습 수업의 운영에서 드러난 한계점 및 교육적 함의에 대해 논의하며 덧붙여 실습선 수업의 성공적인 문제기반학습 설계 및 운영에 대하여 제안 하였다.

Excessive intake of red meat has been associated with colon carcinogenesis. The effect of hemin and zinc on colon carcinogenesis was investigated in male ICR mice. After acclimation for 1 week, five-week-old mice received three s.c. injections (0-2nd weeks of the experiment) of azoxymethane (AOM; 10 mg/kg b.w.) weekly and were treated by 2% dextran sodium sulfate (DSS) in drinking water for the next 1 week to induce aberrant crypt foci (ACF). Mice were fed on AIN-76A purified rodent diet for 6 weeks. There were three experimental groups; control, hemin, and hemin + zinc groups. The daily oral doses of hemin and zinc were 534 mg/kg and 55 mg/kg b.w., respectively. After staining colonic mucosa with 0.2% methylene blue, the ACF, aberrant crypts (AC), and polyps were counted. Lipid peroxidation in liver was evaluated by thiobarbituric acid-reactive substances (TBARS) assay. The numbers of AC, ACF, large ACF (i.e., ≥4 AC/ACF), and polyps in the hemin group were higher than those in the control group. In hemin + zinc group, the numbers of AC, ACF, large ACF were significantly lower compared to the hemin or control groups (p < 0.05), and the number of polyps was also significantly lower compared to that in the hemin group (p < 0.05). The TBARS level in the livers of the hemin + zinc group was significantly lower than that of the hemin group (p < 0.05). These results suggest that hemin enhances colon carcinogenesis and that co-treatment with zinc can protect against the induction of colon carcinogenesis.

Clostridium perfringens (C. perfringens) may cause diarrhea and enterotoxemia in adult and young livestock, leading to problems in the production and management of farms. Four hundred fecal samples were collected from 25 goat farms located in Gyeongsangbuk-do Province in the Republic of Korea. Sixteen C. perfringens strains were isolates from fecal samples, and the isolates were identified as type A (n=11) and type D (n=5). Additionally, α- and ε-toxin genes were detected in 16 and 5 strains by PCR, respectively, and the enterotoxin gene was presented in 2 strains. The antibiotic susceptibility test was performed using the disk diffusion method and E-test method. In the disk diffusion method, ampicillin (n=16) and chloramphenicol (n=15) were highly susceptible to 16 C. perfringens isolates. In the E-test method, ampicillin, amoxicillin, amoxicillin/clavulanic acid and meropenem were susceptible to more than 14 of 16 C. perfringens isolates. This study indicates that administration of antibiotics such as ampicillin, amoxicillin/clavulanic acid and meropenem can prevent and treat C. perfringens infections in goats.

Colorectal cancer (CRC) is the third most prevalent cancer in the world, and heme iron is known to promote the CRC in an animal model. This study was conducted to investigate the effects of ascorbic acid in the presence of hemin on the formation of pre-neoplastic lesions induced by azoxymethane (AOM)/disodium sulfate (DSS) in mice. After acclimation for 1 week, five-week old mice received three s.c. injections (0-2 weeks of the experiment) of AOM [10 mg/kg body weight (BW)] weekly and were treated with 2% DSS in drinking water for the next week to induce aberrant crypt foci (ACF). All animals were fed the AIN-76A purified rodent diet for experimental period of 6 weeks. Experimental groups were then divided into three groups: carboxymethylcellulose (CMC) alone (control), CMC + Hemin, CMC + Hemin + ascorbic acid (AA). The CMC was used as a solvent for hemin. The daily doses were 534 mg/kg BW hemin and 246 mg/kg BW ascorbic acid administered orally. After the colonic mucosa were stained with methylene blue, aberrant crypt foci (ACF), aberrant crypt (AC) and polyps were counted. Lipid peroxidation in liver was evaluated by the thiobarbituric acid-reactive substances (TBARS) assay. The numbers of ACF, AC and large ACF (≥4 AC/ACF) per colon increased in the hemin group compared to the control group, while they decreased significantly in the hemin + ascorbic acid group compared to the control group or hemin group (p<0.01). The number of polyps/colon in the hemin + AA group was significantly decreased compared to the hemin group (p<0.05). In the liver, the TBARS value of the hemin group was significantly higher than that of the control group (p<0.01). Additionally, the TBARS value of the hemin + AA group decreased slightly compared to that of the hemin group. Taken together, these results suggest that hemin can promote colon carcinogenesis in a mouse model and that ascorbic acid has a protective effect against hemin-promoted colon carcinogenesis.

Flame arrestor as end of line flame arrester for endurance burning prevents a light-back at deflagration and stabilized burning (during and after endurance burning) of potentially explosive vapor-air and gas-air mixtures at the end of vent pipes. In a flame arrestor, spring is an important part. The spring load as well as the spring's elasticity determine when the hood is opened. In addition, the spring have to work in high temperature condition due to gas burning. Therefore, it is necessary to analyze mechanical load and elasticity of spring when gas is burned. Based on the dynamic calculation on working process of a specific flame arrestor, analysis of spring is taken. A three dimensional model for spring burned in flame arrestor by using CFD simulation. Results of the CFD analysis are input in FEM simulation to analyze structure of the spring. The simulation results can predict and estimate the spring’s load and elasticity at variation of the spring’s deflection. Moreover, the obtained result can provide makers with references to optimize design of spring as well as flame arrestor.

Process capability is well known in quality control literatures. Process capability refers to the uniformity of the process. Obviously, the variability in the process is a measure of the uniformity of output. It is customary to take the 6-sigma spread in the distribution of the product quality characteristic as a measure of process capability. However there is no reference of process capability when maximum material condition is applied to datum and position tolerance in GD&T (Geometric Dimensioning and Tolerancing). If there is no material condition in datum and position tolerance, process capability can be calculated as usual. If there is a material condition in a feature control frame, bonus tolerance is permissible. Bonus tolerance is an additional tolerance for a geometric control. Whenever a geometric tolerance is applied to a feature of size, and it contains an maximum material condition (or least material condition) modifier in the tolerance portion of the feature control frame, a bonus tolerance is permissible. When the maximum material condition modifier is used in the tolerance portion of the feature control frame, it means that the stated tolerance applies when the feature of size is at its maximum material condition. When actual mating size of the feature of size departs from maximum material condition (towards least material condition), an increase in the stated tolerance-equal to the amount of the departure-is permitted. This increase, or extra tolerance, is called the bonus tolerance. Another type of bonus tolerance is datum shift. Datum shift is similar to bonus tolerance. Like bonus tolerance, datum shift is an additional tolerance that is available under certain conditions. Therefore we try to propose how to calculate process capability index of position tolerance when maximum material condition is applied to datum and position tolerance.

선박용 입형 편흡입 원심 해수펌프의 회전체와 파이프 시스템 내부에 발생한 과도한 손상의 원인을 분석하고자 실제 모 델을 역설계 하였다. 이를 위해 전산유체역학(CFD)을 이용하여 해수냉각펌프의 내부유동 분석을 실시하였다. 결과적으로 역설계를 통 한 대상펌프의 형상 및 경계조건을 설정하여 설계 운전점인 125 /h에서의 펌프 효율은 85.3 %, 양정 32.0미터로 계산되었다. 대상 펌 프의 최고 효율점은 150 /h에서 약 86.2 %로 예측되었으나 실제 운전점과는 차이가 있었다. 최저 유량점인 112.5 /h에서는 저 유량 점 특성상 유동이 불안정하여 해석의 수렴이 좋지 않았다. 선박에서 운전 중인 해수펌프 및 파이프 시스템 전반에 걸쳐 진행 중인 공 동현상의 원인 규명을 통해 개선방안을 도출하고자 하였으나, 입·출구 전체 파이프 시스템의 계산, 각 지관들에 대한 유량 및 유속 측정 등을 통해 보다 명확한 원인분석을 위한 후속연구가 필요하다.