Q fever is a highly infectious tick-borne zoonotic disease caused by Coxiella burnetii, a major pathogen that can cause reproductive disorders in ruminants such as cattle. Being one of the livestock infectious diseases with uncelar causative factors and transmission routes, there is a high possibility of transmission between wildlife, disease vectors, and livestock. Despite extensive research due to its high infectivity and significant economic losses, much of the focus has been on aspects such as pathogen detection, immunodiagnosis, and veterinary medicine. However, understanding the ecological interaction between the vector (ticks) and reservoir hosts (rodents) is crucial for elucidation the transmission dynamics to livestock. In this presentation, we aim to discuss genetic variation analysis approaches and ecological co-occcurrence analysis to understand the transmission pathways between rodents, ticks, and cow.