Sticky mouse-ear chickweed (Cerastium glomeratum Thuill.) is a dominant annual weed of Korea. Control management of such an exotic weed is a challenging task for agronomist and researcher over the years. We evaluated the effect of elevated pH levels on the germination, growth, chlorophyll content, nutrients and hormonal regulation of sticky mouse-ear chickweed under green-house conditions. Our results showed that pH have no significant effect on seed germination except pH3, which reduced germination rate by 10%. Maximum hypocotyl and radicle growth was observed at pH5 and pH7, while hypocotyl failed to emerge at pH 3. Plant growth attributes showed that plant height, fresh biomass, number of leaves and chlorophyll content were higher at pH7 and pH9; while lowest number of leaves (24.8 ± 2.8) and chlorophyll content (313.2 ± 11.2 SPAD) were recorded for pH3. The endogenous ABA levels were significantly higher at pH3 (71.22±5.4ng/g) but lowered at pH7 and pH9 (6.6±0.8 ng/g). The weed nutrients uptake result showed higher Fe (858.47 mg/kg) and Al (835.05 mg/kg) at pH 3 and pH 5; while higher Ca content (4887.2 mg/kg) was observed at pH 5. It was concluded that use of varying pH can play a vital role in the weed management, although its possible adverse impact on endemic flora and fauna needs to be assessed.