Decabromodiphenyl ether (BDE209) is a persistent aromatic compound widely associated with environmental pollutants. Given its persistence and possible bioaccumulation, exploring a feasible technique to eradicate BDE209 efficiently is critical for today’s environmentally sustainable societies. Herein, an advanced nanocomposite is elaborately constructed, in which a large number of titanium dioxide ( TiO2) nanoparticles are anchored uniformly on two-dimensional graphene oxide (GO) nanosheets ( TiO2/GO) via a modified Hummer’s method and subsequent solvothermal treatment to achieve efficient photocatalytic degradation BDE209. The obtained TiO2/ GO photocatalyst has excellent photocatalytic due to the intense coupling between conductive GO nanosheets and TiO2 nanoparticles. Under the optimal photocatalytic degradation test conditions, the degradation efficiency of BDE209 is more than 90%. In addition, this study also provides an efficient route for designing highly active catalytic materials.