Current agriculture encounters several challenges including increase in human population, increased meat consumption from income growth, climate change, and demand for healthier foods. Together this puts a tremendous strain on limited natural resources and on an increasingly fragile ecosystem. Today, 55% percent of habitable land is used for agriculture. Two-thirds (66%) of all annual fresh water withdrawals are used for irrigation. Energy is another vital input for agriculture productivity and experts are predicting increasing global competition for supply sources. Monsanto Company uses biotechnology, plant breeding, and agronomic solution to meet the increased food demand. In June 2008, we issued a three-fold commitment (produce more, conserve more and improve farmer’s lives for agriculture to be sustainable) that we call our Commitment to Sustainable Yield. Here, we present Monsanto pipeline to fulfill our commitment for sustainable agriculture.