We present the results of far-infrared spectral mapping of the Galactic center region with FIS-FTS, which covered the two massive star-forming clusters, Arches and Quintuplet. We find that two dust components with temperatures of about 20 K and 50 K are required to fit the overall continuum spectra. The warm dust emission is spatially correlated with the [OIII] 88 μm emission and both are likely to be associated with the two clusters, while the cool dust emission is more widely distributed without any clear spatial correlation with the clusters. We find differences in the properties of the ISM around the two clusters, suggesting that the star-forming activity of the Arches cluster is at an earlier stage than that of the Quintuplet cluster.