The regional innovation center (RIC) has been closely linked with college or university of the region in the capacity of research collaboration and business activities. In this relationship, the role of college or university becomes utmost important especially in developing countries. This study intends to redirect the role of regional university in Samarkand, Uzbekistan. The tasks for reformulating the agricultural university are associated with the curriculum, the capacity building of faculty, and the operation system of RIC. Finally, this paper suggests that the divided departments of the university should be merged to improve the quality of education and research. Also the university need to focus on extension for agri-business and strengthening lecturer’s competency for development of professional human capitals.