In this present study to investigate the seismic response of an offshore wind turbine, incorporating with bottom fixed Jacket support structure using semi-coupled analysis method. Fully coupled, aero-servo-hydro-elastic simulations and uncoupled seismic simulation have been done to carry out this investigation. The fully coupled simulation is accomplished and executed by FAST 8 (NREL, USA) to determine the global loads, which consists of six components of forces and moments at x-y-z directions of the tower base. In the uncoupled case, transient analysis has been done using the tower base loads as well as seismic loads by ANSYS. This paper presents a precise dynamic analysis, which can evaluate the dynamic response of three crucial points (tower top, tower base and mud line of substructure) under seismic load to make better decision in the case of structural design of wind turbine.