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        검색결과 6

        1.
        2017.06 KCI 등재 구독 인증기관 무료, 개인회원 유료
        Colorectal cancer is a major cause of morbidity and mortality that accounts for over 9% of all incidences of cancer. Additionally, colorectal cancer is widely recognized as an environmental disease related to ill-defined cultural, social and lifestyle factors including physical activity, obesity, cigarette smoking and heavy alcohol consumption. Accordingly, natural phytochemicals and extracts have attracted attention because of their beneficial biological effects. Coenzyme Q10 (CoQ10) is a common supplementary medicine applied to increase bioenergetic capacity in various diseases. Therefore, in this study, we investigated whether CoQ10 treatment has any inhibitory effects and its related cellular mechanisms in human colon cancer HCT116 cells. A MTT assay revealed that CoQ10 slightly decreased the proliferation of HCT116 cells; however, glutathione- and superoxide dismutase- activity were unchanged in response to CoQ10 treatment. A DCF-DA assay revealed that CoQ10 slightly increased ROS release of HCT116 cells. However, in a nitric oxide (NO) assay, CoQ10 significantly increased NO production in a dose-dependent manner. The results of western blot analysis revealed that the protein levels of Bax, p21 and p53 were increased, whereas the protein level of Bcl2 was decreased suggesting that the CoQ10-mediated inhibitory mechanism is associated with apoptotic signaling. Taken together, our findings indicate that CoQ10 has an inhibitory effect on the growth of colon cancer cells via NO production that is associated with regulation of factors involved in apoptotic signaling including Bax, Bcl2, p21 and p53.
        4,000원
        5.
        2012.10 구독 인증기관·개인회원 무료
        An aphid usually stays at one feeding site for a long time for development and reproduction. The green peach aphids, Myzus persicae (Sulzer), feed consistently and regularly throughout all stages of nymphs and adult at one feeding site. In M. persicae, honey dew production, which indicates a state of feeding, occurs at regular intervals within a given stage, and moving, which may be related to escape or dispersal, interrupts feeding, The results of the playback experiments showed that acoustic stimuli with frequencies of 100 and 10000 Hz were effective in inducing feeding repression in M. persicae. That is, HDP occurred less often, and MV occurred more often and longer under acoustic stimuli. In this study, we tested whether the acoustic stimulus effective for inducing feeding suppression decreased reproductive rate in M. persicae. A group of 20 aphids were placed in a host plant and was subject to the acoustic stimulus with two frequency components, 100 and 10000 Hz, for a given time (1, 3, 6, and 12 hours) each day for four days. The result of this experiment showed that the acoustic stimulus did not affect the reproductive rate, regardless of exposure time, in M. persicae.
        6.
        2009.05 구독 인증기관·개인회원 무료
        Males of many cricket species produce calling songs to attract receptive, conspecific females. Calling songs which affected by calling pattern are critical for male mating success, since male with no or limited calling songs are unable to attract female crickets. Investigating among- and within-individual variation in calling pattern may reveal the presence of alternative mating tactics such as attracting females by producing calling songs or being satellites in which males intercept females who are attracted to calling males. In this study, I investigated patterns of calling song production during the entire adulthood of 32 laboratory-reared and 24 field-captured individuals of Teleogryllu emma. Using recording system which can record acoustic signals from up to 32 individuals simultaneously, I measured daily calling output (DCO) and total calling output (TCO) in addition to acoustic parameters of calling songs and classified T.emma males into consistent and inconsistent singers based on the consistency of singing. Consistent singers lived longer, sang longer both in a day and during the lifetime than the inconsistent singers. These results suggest that the consistent singers in this study may be considered to employ the calling tactic. In lab-reared individuals, there seemed to be a trade-off between increasing pulse duration and length of phrases and ling chirp although older males produced calling songs with longer ling chirps and more multiple phrases.