Despite advancements in therapeutic approaches, radiotherapy and cisplatin-based chemotherapy remain primary noninvasive treatments for patients with oral squamous cell carcinoma (OSCC). Moreover, the 5-year survival rate for patients with OSCC has remained almost unchanged for several decades, and many side effects of chemotherapy still exist. In this study, three-dimensional (3D) models of OSCC were established using fibroblasts, and the efficacy of various biological inhibitors was evaluated. A culture of epithelial cells with two types of fibroblasts (hTERT-hNOFs and cancer-associated fibroblasts) within a type I collagen matrix resulted in the formation of a continuous layer of tightly packed cells compared to models without fibroblasts. Furthermore, the effects of biological chemicals, including Y27632, latrunculin A, and verteporfin, on these models were investigated. The stratified formation of the epithelial layer and invasion in OSCC 3D-culture models were effectively inhibited by verteporfin, whereas invasion was weakly inhibited by Y27632 and latrunculin. Collectively, the developed OSCC 3D-culture models established with fibroblasts demonstrated the potential for drug screening, with verteporfin showing promising efficacy.

In today's affluent food environment, investigating factors that facilitate resistance in the face of barriers to health goals may be vital for achieving successful promotion and regulation of health. This study was implemented to investigate the effect of self-compassion on the evaluation and choice of healthy vs. unhealthy food. In Study 1, participants (N = 101) primed with self-compassion evaluated unhealthy food more negatively than those primed with self-esteem. As predicted, however, there was no difference in attitude toward healthy food between the two priming conditions. In Study 2, participants (N = 54) were asked to choose between healthy and unhealthy food and then their self-compassion was measured. Results show that participants with high self-compassion chose healthy food more often than unhealthy food, while those with low self-compassion chose unhealthy food more than healthy food. The implications of the findings are discussed in terms of health campaign strategies and further research into the relation between self-compassion and health behaviors.

담배나방 유충에서 분리한 세포질다각체병 바이러스의 형태, 다각체 단백질 및 핵산의 전기영동상과 바이러스의 병원성을 조사하여 본 바이러스를 이용한 담배나방의 생물적 방제 이용성을 검토하고자 본 실험을 수행하였다. 다각체의 형태는 외관상 6각형으로 0.5~3.7 크기이고 바이러스 입자는 정 20면체로 55nm였다. SDS-PAGE에 의한 다각체 단백질은 단일 롤리？타이드인 24.3 Kd와 5개의 작은 구성분으로 이루어졌다. 바이러스입자는 7개의 폴리？타이드로 구성되어 있으며 분자량은 28.0~133.6 Kd였다. 바이러스 게놈은 10개의 조각으로 된 총 분자량 18.08 Md인 이본쇄 RNA로 각 조각의 분자량 범위는 0.65~2.79 Md이였다. 3령 유충에 대한 담배나방 세포질 다각체병바이러스의 은 이었으며 의 농도에서 에서 16.4일이었다.

To ensure the durability of resistance to blast disease in high-quality japonica rice a long-term rice breeding project to develop a few blast-resistant multiline cultivars was carried out from 1987 to 1999. Seven resistance donors were selected based on

본 연구는 잡종강세를 나타내는 두 조합의 벼 일대 잡종 품종, Shanyou 63, Teyou 53과 inbred계인 밀양 23호 등을 공시하여 벼의 잡종강세 발현기작을 규명코자 실시되었으며, 수행 후 얻어낸 결과를 요약하면 다음과 같다. 1. 종자 단백질 분석을 통해, 잡종강세 발현의 유전적인 특성들이 부분적으로 모본으로 부터 유전된다는 사실을 규명하였다. 2. Hybrid계 벼는 inbred계보다 배아의 크기가 크고 α -amylase 활성 및 chlorophyll함량이 높게 나타났다. 이러한 특성들은 분얼능력, 특히 수량에 밀접한 영향을 끼치는 하부절간의 분얼수와도 관계가 있었으며, Shanyou 63의 경우 다른 inbred계에 비해 60~70%나 분얼력이 높았다. 3. 인위적으로 GA3 0.02 ppm을 처리한 후 α -amylase활성 측정시, hybrid계에는 영향을 미치지 못하였으나 밀양 23은 무처리보다 높은 활성을 나타내었다. 이와 같은 결과는, hybrid계 벼의 종자내에는 이미 충분한 GA를 함유하고 있으며 이것이 초기활력과 관계있는 것으로 추정된다. 4. Cytochrome c oxidase의 활성은 inbred계 보다 hybrid rice에서 2.7~5.5배나 높게 나타났으며, 따라서 hybrid계 벼의 대사작용이 매우 높았다.